Laryngopharyngeal Reflux

by , last modified on 10/11/14
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Do you constantly clear your throat??? What about cough or have persistent mucus/phelgm in the throat? Perhaps even hoarseness or lump sensation in the throat?



A Word on NON-Acidic LPR

In some individuals, they actually have NON-acidic reflux
in which standard anti-reflux medications mentioned on
this webpage will not work. Non-acidic reflux is when
stomach contents other than acid like mucus, pepsin,
bile, and other digestive secretions backflow and cause
damage in the throat. The symptoms are the same as
for LPR, but evaluation and treatment are different. One
test to look for non-acidic reflux is 24 hour Multichannel
Intraluminal Impedance (MII)
testing. Initial therapy
would be to keep the head of bed elevated more than 30
degrees. Best way to do this is by placing a few
bricks/books under the legs at the head of the bed to tilt
the entire bed. Or, sleep in a chair recliner. Or, purchase
a mattress wedge. Sleeping with several pillows is not
adequate as one needs the chest region also to be
higher than your stomach (not just the head).

To read more about non-acid LPR and how it can be
treated, click here for more information.



If you do, you may be suffering from a medical condition called laryngopharyngeal reflux or LPR!

LPR is not quite the same thing as the more common gastroesophageal reflux (GERD). First of all, regardless of whether it is LPR or GERD, reflux is when there is backflow of stomach contents going up towards your mouth instead of down into your intestines. In your esophagus (muscular tube that goes from your mouth to your stomach) there are 2 sphinteric structures to prevent reflux from happening. One sphincter is located at the junction of your stomach and esophagus (LES or lower esophageal sphincter) and the other is located at the junction of your esophagus and throat (UES or upper esophageal sphincter). Reflux occurs when these sphincteric valves fail. As the diaphragm contributes to the lower sphincter, that's why people with hiatal hernias are at risk for reflux since that's when part of the stomach gets pulled (or herniates) into the chest cavity above the diaphragm. Reflux could be either acid (most common) or digestive enzymes (pepsin, bile, etc) and other secretions. Either one can exist without the other. More on non-acidic reflux to the right. —>

So what is the difference between LPR and GERD?

Well, LPR is when the stomach acid gets past both your sphincters and end up in your throat, mouth, and sometimes even up into the back of your nose. GERD is when the stomach acid remains in the chest unable to get past your upper sphincter.

Why don't you have heartburn?

In fact, most people with LPR do not have heartburn. That is a symptom that is mainly associated with GERD. Why is that? Well, the esophagus has a protective lining that prevents acid from doing much damage. In fact, in the normal person, several episodes of reflux is normal and do not cause any heartburn symptoms. In GERD, it is only when there are excessive reflux episodes which wears off the protective lining of the esophagus do symptoms of heartburn begin.

In the throat, there is no protective lining. Therefore, even one single episode of LPR could cause symptoms. If an individual has LPR and only has one or two reflux episodes that get up into the throat, these few episodes would not cause heartburn as the protective lining of the esophagus would be present, but cause LPR symptoms. Indeed, research has shown that it takes as few as three reflux events to cause voicebox inflammation and injury. It has also been found to be a risk factor for throat cancer [more info].

What are the symptoms of LPR?

A patient may have some or all of the following:neck


More rarely, it is a contributing factor to tonsil & adenoid inflammation/hypertrophy as well as chronic sinusitis and eustachian tube dysfunction.

How is LPR diagnosed?

The first clue are your symptoms. If you have any of the above, LPR is a strong consideration. For confirmation, fiberoptic endoscopy would be performed in order to visualize the entire length of your throat. Your physician would look for:

  • Reflux mucus pooling around the voicebox
  • Irritated arytenoids (structures at the back of the vocal folds)
  • Irritated larynx
  • Small laryngeal ulcers
  • Swelling of the vocal folds or around the vocal cords
  • Granulomas in the larynx
  • Significant laryngeal pathology of any type


Further studies may be ordered to diagnose LPR including barium swallow, esophagoscopy, and/or 24 hour pH probe & multichannel intraluminal impedance studies. These studies attempt to either confirm diagnosis or look for other causes of these symptoms (ie, Zenker's Diverticulum, cricopharyngeal dysfunction, etc).

A simple spit test can also be performed to determine if LPR is present as well. This test is currently not FDA approved yet and as such, is a test that is NOT covered by insurance at this time. Due to a special arrangement with RDBiomed who performs the testing, this test can be obtained in our office at a discounted price of $125 (compared to normal price of $175). Price includes the kit, test supplies, and courier shipping service. This test is ONLY offered to current patients of ours. If you are not a patient of ours, you can purchase the test online here. We recommend the standard 3 sample peptest.


videoWatch Video of How a 24 hour pH and Impedance Testing is Performed

How is LPR treated?

  • Stress Reduction: Stress increases risk of GERD and LPR by stimulating acid production in your stomach.
  • Avoid the following foods
    • Spicy, acidic and tomato-based foods like Mexican or Italian food.
    • Acidic fruit juices such as orange juice, grapefruit juice, cranberry juice, etc..
    • Fast foods and other fatty foods.
    • Caffeinated beverages (coffee, tea, soft drinks) and chocolate.
    • Alcohol
    • For those suffering from phlegmy throat, avoid dairy, wheat, and egg which are probably the top 3 most common mucus generating foods products.
  • Adjust your meals:
    • Do not gorge yourself at mealtime
    • Eat sensibly (moderate amount of food)
    • Eat meals several hours before bedtime
    • Avoid bedtime snacks
    • Do not exercise immediately after eating
  • Lose weight! Being overweight can dramatically increase reflux.
  • Elevate the head of your entire bed 4-6 inches by placing books, bricks, or a block of wood under the legs of the bed to achieve a 20-30 degrees or more slant.
  • Avoid tight belts and other restrictive clothing.
  • Stop smoking! Smoking dramatically increases reflux.


If these more conserative measures do not adequately address LPR, there are medications one can take. Such medications include proton pump inhibitors like Prilosecamazon or Prevacidamazon (which are over-the-counter) as well as nexium, protonix, etc as well as H2-blockers like zantacamazon, pepcidamazon, axidamazon, etc. There are also prescriptions your physician may prescribe. Be aware that these medications only work for acid reflux. If you are suffering from non-acidic reflux, alternative treatments need to be pursued (click for more information).

Treatment usually will last from 6 weeks to as long as 3 months. Why so long before symptom resolution? Well, because once damage to the lining occurs, it takes time for it to heal and acid suppression is required throughout the healing. This would be no different than if you burned your hand with acid which would take time to heal with resolution of the discomfort.

Unfortunately, medications do not help everybody. Indeed, one study found that up to 30% of patients will not improve with reflux medications.

If medications do not help and the symptoms are unacceptable, surgical options can be considered including the gold-standard Nissen Fundoplication surgical procedure performed by general surgeons. Trans-Oral Fundoplication is a less invasive option that requires no incisions that may also help.

If LPR is affecting your quality of life, please contact our office for an appointment.

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Any information provided on this website should not be considered medical advice or a substitute for a consultation with a physician. If you have a medical problem, contact your local physician for diagnosis and treatment. Advertisements present are clearly labelled and in no way support the website or influence the contents.

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